AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis

Summary: Doxorubicin induces myocardial injury and fibrosis.Still, no effective interventions are available.AP39 is an H2S donor that explicitly targets mitochondria.This study investigated whether AP39 could improve Cologne doxorubicin-induced myocardial fibrosis.Doxorubicin induced significant myocardial fibrosis while suppressing mitophagy-relat

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